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Related post: up. There was a significant relationship between plasma and urine histamine
when measured concurrently. Thus, increased plasma histamine appears to
differentiate systemic mastocytosis from other systemic disorders of mast
cells.
Scintigraphic findings in Reminyl Galantamine 10 cases of systemic mastocytosis were correlated
to plasma histamine levels. Bone scans showed more widespread involvement
than radiographs in patients with diffuse disease and detected a greater
number of focal lesions. Four bone scan patterns were noted: 1) normal,
2) focal, 3) multifocal, and 4) diffuse. Plasma histamine levels were
progressively greater as the scan pattern progressed from normal to diffuse.
Thus, bone scintigraphy is useful in both the diagnosis and in assessing the
severity of systemic mastocytosis.
The value of combination H^ and H antihistamines or cromolyn sodium in the
S)nnptomatic relief of systemic mastocytosis was assessed. Neither drug
regimen significantly differed in its efficacy, although antihistamines
appeared somewhat more useful in releaving pruritis. Neither drug combination
altered plasma histamine levels.
18- 23
PHS 6040 (Rev. 1/83)
GPO 895-100
PERIOD COVERED
October 1. 1982 to September 30, 1983
PRINCIPAL INVESTIGATOR Reminyl Er (List other profeulonal pertonnel on subsequent pages.)
(Name, title, laboratory, and institute affiliation)
Dean D. Metcalfe, M.D.. Senior Clinical Investigator, LCI, NIAID
DEPARTMENT OF HEALTH Reminyl 4mg AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
ZOl AI 00250-02 LCI
TITLE OF PROJECT (80 characters or less. Title must fit on one line between the borders.)
Clinical and Basic Studies on Inflammatory Diseases of the Gastrointestinal Tract
COOPERATING UNITS (if any)
None
LAB/BRANCH
Laboratory of Clinical Investigation
SECTION
Allergic Diseases Section
INSTITUTE AND LOCATION
NIAID. NIH. Bethesda. Maryland 20205
TOTAL MANYEARS:
2.15
PROFESSIONAL:
2.15
CHECK APPROPRIATE BOX(ES)
lyi (a) Human subjects
□ (a1) Minors
□ (a2) Interviews
□ (b) Human tissues
□ (c) Neither
SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)
In a clinical study on immediate adverse reactions to foods in adults , a
positive skin test to a given food correlated with reproduction of symptoms
on double-blind food challenge . Patients whose symptoms could be reproduced
tended to be atopic , have multiple positive skin tests to foods and inhallents,
and to have higher IgE levels . Plasma and urine histamine levels generally
remained normal during clinically positive food challenges unless the reaction
was generalized. Positive reactions often involved the gastrointestinal tract,
respiratory tract, and skin . Specific IgE to foods did not rise significantly
after challenge.
Cultured mouse mast Reminyl Xl cells with characteristics resembling those of mucosal mast
cells have been examined for their response to degranulating agents and
compounds known to modulate release. These cells released histamine to
immunologic stimuli, concanavalin A , ionophores , and substance P , but were
refractory to several other agents including compound 48/80, gastrin, and
neurotension. Release was inhibited by theophylline Galantamine Reminyl , but not cromolyn
sodium. Experiments are underway to isolate mucosal mast cells directly
from animal intestinal mocosa using a combination of Buy Reminyl enzymatic dispersion ,
elutriation , and gradient centrifugation.
18- 24
PHS 6040 (Rev. 1/83)
GPO 895-100
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
ZOl AI 00269-02 LCI
PERIOD COVERED
October 1. 1982 through September 30. 1983
TITLE OF PROJECT (80 charactere or less. Title must fit on one line between the borders.)
Phagocytic Cell Activation
PRINCIPAL INVESTIGATOR (List other profeeaional personnel on subsequent pages.)
(Name, title, laboratory, and Institute affiliation)
Bruce E. Seligmann Staff Fellow
LCI, NIAID
COOPERATING UNITS wany; Qy. . ThoRias ChusBcl (LMI, NIAID), Dr. Harry Malech, Yale
University School of Medicine, Dr. Marc Friedman, Department of Microbiol.,
Georgetown Medical Center
LAB/BRANCH
Laboratory of Clinical Investigation
SECTION
Bacterial Diseases Section
NSTITUTE AND LOCATION
NIAID, NIH, Bethesda, MD
TOTAL MANYEARS:
1 .1
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